Dr. Matthew Hancock and Dr. Joseph Barakat discussed "Computational Fluid Dynamics Investigation of Lyophilized Drug Product Reconstitution within Dual-Chamber Autoinjectors: Optimizing Device Performance through Simulation" at the PDA Universe of Pre-Filled Syringes and Injection Devices Conference 2024.
Dual-chamber autoinjectors keep freeze-dried drug product and liquid diluent separate until just before use, which offers advantages such as extended shelf life and drug stability. Prior to injection, the drug product is combined with diluent in a process called reconstitution. Ensuring effective and efficient reconstitution is vital for accurate dosing, therapeutic efficacy, patient safety, and ease of use. Computational fluid dynamics (CFD) simulations enable us to predict the reconstitution process and understand how parameters for device design, operation, and drug product affect reconstitution efficiency.
The conference took place in Phoenix, AZ, October 22-23, 2024. This talk was on day 2 of the conference (October 23), as Part of B4: Innovative Drug Delivery: Ocular, Reconstitution, and Intranasal.
Veryst also presented a poster at the event – “Multiphysics Simulation of Needle Clogging in Prefilled Syringes” – addressing how needle clogging in prefilled syringes can impede drug product injection and reduce drug product quality. Combining rheological analyses with suspension mechanics simulations can predict the onset of clogging and elucidate design rules for prefilled syringes.
Veryst was also a sponsor of the conference. Learn more at https://www.pda.org/global-event-calendar/conferences/pda-universe-of-pre-filled-syringes-and-injection-devices-conference-2024