Inkjet printing, the precise deposition of micro-scale droplets onto solid substrates driven by controlled ejection and surface wetting, enables high-resolution feature formation for printed electronics, functional coatings, and diagnostic device manufacturing. In this case study, we present advanced simulations of inkjet droplet impact and spreading and their dependence on substrate wettability. Such simulations inform substrate selection and process design decisions to improve feature resolution, print reliability, and manufacturing efficiency.